Roy Kishony

This study shows that de novo mutations in Burkholderia dolosa cause phenotypic switching, with O-antigen loss increasing immune cell uptake but reducing lung competitiveness, depending on infection duration and tissue localization.

The paper compares two models for predicting drug combination effects in E. coli and finds Bliss additivity outperforms Loewe as more drugs are added.

This study shows that population diversity can reduce the effectiveness of antibiotic cycling strategies by enabling rare positive cross-resistant mutants to emerge.