Joe Swift

This study quantifies age-related changes in kidney extracellular matrix turnover and identifies structural and functional alterations linked to fibrosis.

The paper investigates collagen fibril formation in fibroblasts, showing it occurs at the plasma membrane independently of secretion and involves endocytosis.

This study shows that GMAP210 and Golgin-160 have distinct roles in maintaining Golgi structure, both necessary for efficient ECM secretion and modification.

The paper uses stable isotope labeling and mass spectrometry to show that tendon ECM has circadian and permanent pools with distinct turnover rates, which change with age.

This study optimizes self-assembling peptide hydrogels to better support mammary epithelial cell organoid formation compared to Matrigel.

The paper identifies age-related biomarkers in human skin and tendon proteomes using peptide location fingerprinting and a new webtool.

This study shows that increased ECM stiffness causes genomic damage in mammary epithelial cells through RhoA-dependent aldehyde metabolism changes.

This paper introduces BayesENproteomics, a Bayesian elastic net method for quantifying proteoforms, showing improved accuracy in protein abundance and PTM quantification across dynamic ranges.

This study examines how aging and estrogen deficiency affect skin matrix composition and mechanics in mice, finding contrasting effects on tensile strength and collagen levels.