ImmunologyNature CommunicationsPeer-reviewed
Rapid establishment of a tumor-retained state curtails the contribution of conventional NK cells to anti-tumor immunity in solid cancers
Isaac Dean, Colin Y.C. Lee, Zewen Kelvin Tuong…·David R. Withers
This study shows that conventional NK cells rapidly lose effector functions upon entering tumors and that IL-15:IL-15Ra complexes can restore their function and tissue-residency.