Stephanie S. Kim

The paper identifies and validates four kynureninases using homology searches and protein language models, with the most active one showing significant tumor reduction in mouse models.

Foldseek's 3Di tertiary-interaction alphabet enables structure search four to five orders of magnitude faster than Dali and TM-align at 86% and 88% of their respective sensitivities.

The paper uses AlphaFold2 to analyze protein structures from 21 organisms, identifying 26 novel superfamilies and expanding structural diversity insights.