Ash A. Alizadeh

This study identifies IKAROS as a factor associated with antigen escape in B-ALL, showing that low IKAROS levels lead to reduced B-cell antigen expression and resistance to CD19- and CD22-targeted therapies.

This study identifies four molecular subtypes of Hodgkin lymphoma using multimodal data, revealing distinct clinical features and immune ecosystem dynamics.

The paper presents a workflow using machine learning to optimize protein function and reduce immunogenicity in cell and gene therapies.

This study identifies unique immune environments in DLBCL associated with response to immunotherapy using an integrative multi-omic approach.

The paper identifies TCF4 overexpression driven by 18q21.2 gains as a mechanism promoting IgM expression in ABC-like DLBCL and shows BET inhibitors can suppress it.