Tsukasa Okiyoneda

The paper shows SELS and SELK regulate NRF1 stability and transcriptional activity through ER-associated degradation, affecting proteasome subunit expression.

This study shows Ca2+ induces PDIA6 phase separation, enhancing proinsulin folding and preventing aggregation through recruitment of PDIA3.

The paper identifies AMFR as a compensatory factor for ERAD pathway function when RNF5/185 is deficient, showing its role in degrading mutant CFTR.

This study identifies HERC3 as a cytosolic E3 ligase that facilitates ERAD of specific polytopic membrane proteins like CFTR, distinct from RNF5/185.