Ken-ichi Noma

This study identifies senomorphic and senolytic agents that counteract UV-induced senescence in XP-derived melanocytes, reducing SASP gene expression and related pathway activation.

This study shows that targeting CCND1-CDK6 reduces DNA damage, inflammation, and age-related decline in mice by suppressing SASP and ISG expression.

The paper shows that local chromatin decompaction during mitosis, driven by transcription factors and elongation, shapes chromosome structure and domain boundaries.

This study identifies a condensin-mediator interaction in fission yeast that is essential for mitotic chromosomal organization and segregation.

This study explores combining cisplatin and the senolytic agent ABT-263 to treat angiosarcoma, showing that low-dose cisplatin induces senescence, which is then eliminated by ABT-263, reducing chemotherapy side effects.