This study identifies senomorphic and senolytic agents that counteract UV-induced senescence in XP-derived melanocytes, reducing SASP gene expression and related pathway activation.

DOI 10.1186/s13287-026-05227-7

humanbulk RNA-seq

𝕏 PostBluesky

Genetic & Genomic MedicineNature CommunicationsPeer-reviewedFeb 17, 2025

RNA methyltransferase SPOUT1/CENP-32 links mitotic spindle organization with the neurodevelopmental disorder SpADMiSS

Avinash V. Dharmadhikari, Maria Alba Abad, Reza Maroofian…·Universitat Autònoma de Barcelona. Departament de Medicina

The paper identifies SPOUT1/CENP-32 as a causative gene for SpADMiSS, linking its dysfunction to mitotic spindle defects and neurodevelopmental disorders.

DOI 10.1038/s41467-025-56876-w

zebrafishwhole-exome sequencing

𝕏 PostBluesky

GenomicsbioRxivPreprintJun 26, 2024

A role for condensin-mediator interaction in mitotic chromosomal organization

Osamu Iwasaki, Sanki Tashiro, Claire Chung…·Ken-ichi Noma

This study identifies a condensin-mediator interaction in fission yeast that is essential for mitotic chromosomal organization and segregation.

DOI 10.1101/2024.06.26.600663

fungi (other)DNA methylation

𝕏 PostBluesky

Cancer BiologyJournal of Investigative DermatologyPeer-reviewedApr 1, 2024

Chemo-senolytic therapeutic potential against angiosarcoma

Xuebing Wang, Claire Yik-Lok Chung, Ai Yoshioka…·Ken-ichi Noma

This study explores combining cisplatin and the senolytic agent ABT-263 to treat angiosarcoma, showing that low-dose cisplatin induces senescence, which is then eliminated by ABT-263, reducing chemotherapy side effects.

6 citations

humanexperimental assay

𝕏 PostBluesky