Hefei Zhang

The paper introduces Worm Perturb-Seq (WPS) to perform high-resolution RNA-seq on perturbed C. elegans, identifying gene regulatory networks and showing pairwise modularity in nuclear hormone receptor regulation.

This study identifies Kiaa1024L/Minar2 as essential for hearing by regulating cholesterol distribution in hair bundles, showing that its loss causes deafness in zebrafish.

The paper shows that different bacteria modulate tamoxifen toxicity in C. elegans through fatty acid metabolism, with varying death mechanisms and FA profiles.

The paper manually annotates and visualizes metabolic pathways in C. elegans, providing pathway maps for metabolic enrichment analysis of transcriptomic data.

The paper identifies two mechanisms by which vitamin B12 regulates the methionine/S-adenosylmethionine cycle in C. elegans, involving transcriptional adjustments via nuclear hormone receptors.