Andrew Michael Frey

This study identifies biallelic UQCC1 variants as a cause of early-onset mitochondrial disease by impairing complex III assembly and function.

The paper introduces a hierarchical Bayesian model to handle missing data and improve differential expression analysis in proteomics by accounting for uncertainty in missing values.

This study uses single-cell proteomics to identify protein-defined chondrocyte states and other cell populations in human osteoarthritic joints, complementing single-cell transcriptomics.

This study uses proteomic analysis to reveal reprogramming in macrophages during efferocytosis, showing an alternatively activated phenotype and secretome-driven reprogramming of naive macrophages.

The paper identifies insulin receptor ubiquitination as a regulator of collagen secretion in human skin through comparative ubiquitinomics of healthy and CYLD syndrome skin.

This study identifies and characterizes novel T6SS effectors in Chromobacterium violaceum, revealing RhsF as an antibacterial toxin with FIX and ADP-ribosyltransferase domains.

The paper introduces Ubi-SCAPE, a method to purify poly-ubiquitylated proteins with high specificity, reducing contaminants and improving reproducibility.

The paper introduces a cost-effective single-cell proteomics method to analyze skin tumors in CYLD cutaneous syndrome, identifying a novel tumor-associated macrophage signature.

The paper identifies de novo truncating variants in XRN1's C-terminal region causing lethal infantile mitochondrial cardiomyopathy by disrupting its interaction with EDC4.

This study evaluates two mass spectrometry-based phenotypic screening approaches for identifying anti-inflammatory compounds in macrophages and compares them to cytokine profiling.

This study identifies Tfe2 as a novel antifungal effector that inhibits protein translation and hyperactivates TORC1, leading to cellular remodeling in yeast.

The paper identifies a distinct BAM complex in Bacteroidetes using structural biology and proteomics, revealing an expanded role compared to Proteobacteria.

The paper evaluates protein quantitation in DIA proteomics using controlled experiments on two mass spectrometry platforms, identifying over 10,000 proteins and highlighting the impact of post-processing on accuracy and false quantitative rates.

This paper introduces a new N-terminomic method, TAGS-CR, to identify substrates of the S. aureus V8 protease in human neutrophils, revealing 350 targets that modulate neutrophil function and immune response.

The paper develops a flow cytometry-based method combined with ultra-sensitive proteomics to study host-pathogen interactions in Salmonella-infected macrophages, revealing new insights into virulence factor induction and phagosomal dynamics.

This study identifies non-canonical NF-κB signalling as a therapeutic target in CYLD cutaneous syndrome and shows that IKK inhibition reduces tumor viability in patient-derived models.

The paper compares proteomic profiles of murine macrophage cell lines to primary and immortalised bone marrow-derived macrophages, identifying J774A.1 as the most similar to primary cells.

This paper uses proteomics to show trilaciclib induces senescence in CML and NSCLC cells by stabilizing CDK4/6 and activating autophagy.