David J. Christini

This paper develops a computational model to identify and correct artefacts in voltage-clamp experiments, improving the accuracy of ion channel recordings.

This study introduces RICP to quantify ionic current heterogeneity in iPSC-CMs and identifies key currents determining action potential variability.

This paper optimizes a cardiomyocyte model using a genetic algorithm to enhance repolarization reserve, revealing an unexpected role of increased late sodium current in maintaining action potential stability.