Hiroshi Asahara

This study shows that tendon-specific PIEZO1 activation increases neural drive to muscle during high-load ballistic movements, without affecting muscle mass or myogenic gene expression.

This study profiles human cartilage across OA grades, revealing changes in fibronectin expression, splicing, and receptor signaling during disease progression.

The paper uses single-nucleus multiome sequencing to analyze subchondral bone in OA, finding increased osteocyte SMAD2/3 activity and chondrocyte-derived FN1 signaling with disease severity.

This study identifies NAT10 as a regulator of CAG repeat-containing mRNA stability and links its upregulation in spaceflight to metabolic reprogramming in mouse liver.

This study introduces TEMPO-editing, a method to generate multiple-gene-edited mice in a single step, demonstrating its effectiveness in creating double-gene-edited mice with spatial and temporal specificity.

This study identifies CD55 and CD248 as novel surface markers for tendon stem/progenitor cells using single-cell and single-nucleus sequencing in mouse Achilles tendon.

This study shows that Scx-positive tendon cells are essential for proper muscle attachment and patterning in mouse embryos, revealing a novel tissue-tissue interaction in musculoskeletal development.

This study identifies KLF4 as a potential transcriptional regulator of angiogenesis and neural development in sevoflurane-exposed mice brains.

The paper identifies TruB1 as a regulator of let-7 miRNA maturation and function, showing it enhances let-7 processing through direct interaction with pri-let-7.

This study shows the Lin28a/let-7 pathway regulates Hox gene expression during axial patterning by modulating Polycomb complex occupancy in vertebrates.

This study shows that switching Neat1 isoforms from Neat1_1 to Neat1_2 in mice leads to loss of Neat1_1, increased Neat1_2, and hyperformed paraspeckles without affecting mouse development or growth.

The paper investigates the roles of NEAT1 isoforms, finding that NEAT1_1 is dispensable for tissue homeostasis and cancer cell growth, while NEAT1_2 is critical for paraspeckle formation and function.