Sebastian Lourido

The paper uses crosslinking mass spectrometry to map protein interactions in Toxoplasma gondii, identifying novel components of essential complexes and revealing structural diversity in mitochondrial machinery.

Brieflow is a computational pipeline for analyzing optical pooled screening data, demonstrating its ability to recover biological modules missed by existing methods.

The paper identifies two distinct SWI/SNF complexes in Toxoplasma gondii that have different roles in transcriptional regulation during the cell cycle and development.

The paper investigates pathogen-specific sickness states by analyzing immune and neural responses across multiple scales in various inflammatory models.

The paper identifies host N-glycosylation and cholesterol biosynthesis as required for Toxoplasma rhoptry discharge, mediated by the MIC1/4/6 complex clustering host factors.

This study confirms that Toxoplasma gondii induces a transient increase in host cell plasma membrane conductance during invasion, suggesting a perforation mechanism for rhoptry protein delivery.

This study identifies how 5' UTR features and upstream AUGs regulate translation efficiency in Toxoplasma gondii using ribosome profiling and synthetic reporter assays.

This study investigates the role of the ingestion pathway in Toxoplasma gondii nutrient acquisition by analyzing mutants lacking key pathway components, revealing reliance on biosynthetic pathways and highlighting the pathway's role in nutrient scarcity.

This study shows immune pressure targets Toxoplasma gondii bradyzoites, which mitigate tissue damage and promote host-parasite survival.

The paper identifies differentially-localized protein isoforms generated by alternative start codon selection and shows their role in mitochondrial function, evolution, and disease.

This study identifies TgATG9 as essential for autophagosome formation and chronic Toxoplasma gondii infection.