Hejian Xiong

This study develops photoswitchable nanovesicles for controlled in vivo neuropeptide delivery, showing they modulate hippocampal circuit dynamics and social behavior in mice.

This study uses plasmonic nanovesicles to measure diffusion in GBM and finds the tumor margin has the lowest diffusion coefficient, indicating it acts as a diffusion barrier.

The paper develops a method to image the entire brain extracellular matrix in live tissue using a protein-reactive dye, enabling visualization of ECM structures in various brain conditions.

The paper develops an all-optical method to study neuropeptide volume transmission in mouse neocortex, finding faster SST transmission in a chemically degraded extracellular matrix.

This paper demonstrates a method to selectively open the blood-brain barrier using light-stimulated nanoparticles targeting tight junctions, enabling macromolecule and gene therapy vector delivery without neurotoxicity.