Kazutoshi Takahashi

This study identifies EIF3H as essential for human primed pluripotency by regulating translation of metallothionein genes, impacting proliferation and differentiation.

This study compares CRISPRi and CasRx for gene knockdown in human pluripotent stem cells, finding CRISPRi provides faster and stronger repression but slower recovery, while CasRx offers reversible knockdown with isoform resolution but lower efficiency.

This study identifies EIF3D as a key regulator of primed pluripotency through selective translational control of signaling pathways and p53 regulators.

The paper identifies 20 post-transcriptionally regulated genes essential for pluripotent stem cell survival, showing their protein upregulation and nuclear-to-cytoplasmic mRNA localization.