Knut Woltjen

This study investigates how dysregulated flow responses in endothelial cells contribute to Sturge-Weber syndrome pathogenesis using cellular models and omics analyses.

This study identifies EIF3H as essential for human primed pluripotency by regulating translation of metallothionein genes, impacting proliferation and differentiation.

This study compares Cas9 and Prime Editing (PE) in human iPS cells, showing PE's superior precision and demonstrating how sorting by PE expression affects allelic editing outcomes.

This study improves transgenic mouse production efficiency using piggyBac, enabling phenotyping in the founder generation and demonstrating application with bacterial artificial chromosome transgenes.

This study generates marmoset PGCLCs from iPSCs using mRNA transfection and shows their differentiation into gonocyte-like cells in xenoreconstituted testes.

This paper develops CaRTRIDGE, a system using CRISPR-associated proteins to control mRNA translation, creating orthogonal switches and synthetic circuits in mammalian cells.

This study shows that naive human pluripotent stem cells can recapitulate trophoblast development in vitro, producing cells that resemble human placental trophoblasts.

This study models the human segmentation clock using iPSC-derived presomitic mesoderm, identifying oscillatory genes and validating disease-related gene effects.