Author

Remkes A. Scheele

Columbia University Irving Medical CenterORCID 0000-0002-5354-8286Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Approach:biophysical modeling· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein design· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Abiha KazmiiD· 1 shared Anum Azam GlasgowiD· 1 shared Florian HollfelderiD· 1 shared Friederike E. H. NintzeliD· 1 shared Ipek Simay GokuluiD· 1 shared Jing LiiD· 1 shared Lamia ChowdhuryiD· 1 shared Lila TayloriD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

Abiha KazmiORCID

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2 papers

Recent·Most cited

Cancer BiologyNature CommunicationsPeer-reviewedMar 3, 2026

A Hotspot Phosphorylation Site on SHP2 Drives Oncoprotein Activation and Drug Resistance

Prashath Karunaraj, Remkes Scheele, Malcolm L. Wells…·Neil Vasan

This paper identifies phosphorylation of SHP2 at tyrosine 62 as a mechanism of resistance to SHP2 inhibitors and a new drug target.

7 citationstop 2%

humanproteomics

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BiochemistryACS CatalysisPeer-reviewedApr 10, 2024

Ultrahigh throughput evolution of tryptophan synthase in droplets via an aptamer-biosensor

Remkes A. Scheele, Yanik Weber, Friederike E. H. Nintzel…·Florian Hollfelder

This paper develops a DNA aptamer biosensor to enable high-throughput screening of tryptophan synthase variants in droplets, identifying 5-fold improved enzymes.

17 citations

proteomicsexperimental assay

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