Benjamin Murray Heineike

The paper identifies genetic and environmental factors influencing multicellular-like phenotypes in fission yeast through experimental and genomic analyses.

This study uses AlphaFold2 to analyze how metabolism influenced enzyme structural evolution across 400 million years by examining 11,269 enzyme structures and their metabolic reactions.

The paper shows yeast cells can cooperatively compensate for methionine auxotrophy by using a new homocysteine synthase, HSU1, to re-assimilate hydrogen sulfide.

Inserting theophylline aptamers into the sgRNA yields ligand-activated and ligand-deactivated guides that tune CRISPRi in E. coli over 11x to 13x dynamic ranges, enabling two-ligand multiplexing.