Uxía Gurriarán‐Rodríguez

The paper surveys awareness of extracellular vesicles' translational potential across academia and industry, highlighting growing interest and spin-out efforts in EV-based products.

This study shows that Wnt7a is critical for muscle regeneration in dystrophic mice, and systemic delivery of Wnt7a-containing extracellular vesicles can rescue regeneration deficits.

This study identifies the structural mechanism by which Wnt7a binds to exosomes for secretion, showing it is independent of palmitoylation and involves a dilysine motif interacting with COPB2.

The paper develops a protocol combining Tangential Flow Filtration and Size Exclusion Chromatography to isolate high-purity extracellular vesicles from muscle tissue, separating Wnt7a-bound EVs from free Wnt7a.