Christopher D. Huston

This paper identifies UCB-9721 as a potent inhibitor of T. gondii MyoA, showing greater potency than KNX-002 and inhibiting related apicomplexan parasites.

This paper develops an organoid-based culture system and a fertilization reporter to study Cryptosporidium parvum sexual reproduction, enabling real-time observation and validation of fertilization and oocyst production.

The paper develops a high-throughput in vitro screen for Babesia duncani using propidium iodide, identifying HDAC inhibitors as potent leads.

This study identifies potent PDE-V inhibitors effective against Cryptosporidium parvum in immunocompromised mice, with minimal off-target effects.

This study identifies small-molecule compounds that modulate sexual differentiation in Cryptosporidium using a multi-readout imaging assay and confirms translational repression and an AP2 transcription factor's role in this process.