Joshua Jeong

This study identifies LENG8 as a conserved RNA nuclear retention factor that prevents misprocessed mRNAs and noncoding RNAs from being exported, ensuring proper nuclear quality control.

This study shows that chromatin buffers torsional stress during transcription by enabling Pol II to transcribe through nucleosomes more efficiently than on single-nucleosome substrates.

This study identifies a new role for human topoisomerase IIα in promoting chromatin condensation through a polymer-collapse phase transition, independent of its catalytic activity.

This study shows that chromatin enhances topoisomerase II processivity under both high and low torsional stress, with topo II relaxing over 6000 DNA turns on plectonemic DNA.