Author

Joyce H. Lee

Johns Hopkins UniversityORCID 0000-0003-0459-5999Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

James M. BergeriD· 2 shared James T. InmaniD· 2 shared Joshua JeongiD· 2 shared Meiling WuiD· 2 shared Michelle Dong WangiD· 2 shared Robert M. FulbrightiD· 2 shared Curtis BeckiD· 1 shared Gundeep SinghiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBiophysics

James M. BergerORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintOct 15, 2024

Human Topoisomerase IIα Promotes Chromatin Condensation Via a Phase Transition

Meiling Wu, Curtis Beck, Joyce H. Lee…·Michelle Dong Wang

This study identifies a new role for human topoisomerase IIα in promoting chromatin condensation through a polymer-collapse phase transition, independent of its catalytic activity.

10 citations

humanDNA methylation

𝕏 PostBluesky

BiophysicsNature CommunicationsPeer-reviewedOct 27, 2023

Chromatinization Modulates Topoisomerase II Processivity

Jaeyoon Lee, Meiling Wu, James T. Inman…·Michelle Dong Wang

This study shows that chromatin enhances topoisomerase II processivity under both high and low torsional stress, with topo II relaxing over 6000 DNA turns on plectonemic DNA.

27 citations

experimental assaychromatin & epigenetic regulation

𝕏 PostBluesky