Author

Simon F. Roy

Institut du cancer Rosalind & Morris GoodmanORCID 0000-0002-5444-0349Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:spatial domain detection· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Abdelhakim KhellafiD· 1 shared Afşar BarlasiD· 1 shared Alexandre Archambault-MarsaniD· 1 shared Ali KassabiD· 1 shared Basile Tessier‐CloutieriD· 1 shared Camille Beaussier· 1 shared David J. H. F. KnappiD· 1 shared Elham Dianati· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

Abdelhakim KhellafORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 9, 2026

Spatial multi-omics resolve epithelium-fibroblast gradients and highlight NESTIN-NOTCH1-expressing subepithelial fibroblasts during human pancreatic tumorigenesis

Maëlle Batardière, Myriam Iliana Ibanez-Rios, Abdelhakim Khellaf…·Vincent Quoc‐Huy Trinh

This study uses spatial multi-omics to identify NESTIN-NOTCH1-expressing fibroblasts in IPMNs and their role in pancreatic tumorigenesis.

DOI 10.64898/2026.09.04.749182

humanspatial transcriptomics

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Cancer BiologyCancer ResearchPeer-reviewedFeb 24, 2025

Tumorigenesis driven by the BRAF V600E oncoprotein requires secondary mutations that overcome its feedback inhibition of migration and invasion

Sunyana Gadal, Jacob A. Boyer, Simon F. Roy…·Neal X. Rosen

This study shows that BRAFV600E mutations inhibit cell migration and invasion through feedback inhibition of RAC1, requiring secondary mutations to overcome this block and enable tumorigenesis.

7 citations

humanDNA methylation

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