Jack M. Copping

This study solves the structure of the TRAP substrate-binding protein AaSiaP in different conformations, revealing how it binds N-acetylneuraminate and stabilizes a closed state.

This study shows that de-glycosylation of N207 in DENV NS1 reduces viral fitness and enhances clearance by limiting PD-L1/PD-1 mediated T cell apoptosis.

The paper reports the cryo-EM structure of a TRAP transporter and elucidates its mechanism of sodium-driven substrate uptake.