Author

Anna Konopka

Flinders UniversityORCID 0000-0002-5487-6003Unclaimed ORCID profile · follow to get notified of new preprints

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Neuroscience· 1

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Approach:experimental assay· 1 Organism:mouse· 1

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Harman SharmaiD· 1 shared Mary‐Louise RogersiD· 1 shared Megan FowleriD· 1 shared Sushma Koirala· 1 shared Yee Lian ChewiD· 1 shared

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2025-2025 · peak 1/yr

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1 shared paperNeuroscience

Harman SharmaORCID

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1 paper

Recent·Most cited

NeurosciencebioRxivPreprintDec 10, 2025

ALS/FTD-associated TDP-43 mutations promote fragility of genes governing excitatory neurotransmission via topoisomerase IIβ impairment

Harman Sharma, Sushma Koirala, Megan Fowler…·Anna Konopka

This paper shows that ALS/FTD-linked TDP-43 mutations cause DNA breaks in genes controlling excitatory neurotransmission by impairing topoisomerase IIβ function.

DOI 10.64898/2025.12.08.693088

mouseexperimental assay

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