Stanley Nattel

This study compares mitochondrial function and TCA cycle activity in sheep resistant to atrial fibrillation (AF) versus those that develop stable AF, finding differences in redox state and energy metabolism.

The paper identifies a 127-gene core network in human astrocytes linking aging to neurodegenerative and cardiovascular diseases through proteostasis and stress signaling.

This study examines mitochondrial changes during atrial fibrillation in animals and humans, showing early hyperfunction and damage, and demonstrates that mitochondrial-targeted therapy can prevent adverse remodeling and AF sustainability.

The paper identifies shared proteins and pathways between cardiovascular and cognitive diseases using protein interaction network analysis, highlighting oxidative and glycative stress mechanisms in vascular cognitive impairment.

This study profiles transcriptomic changes in canine atrial fibrillation models at disease onset, identifying novel genes and pathways involved in AF pathophysiology.

The paper applies renewal theory to model phase singularity dynamics in cardiac fibrillation across species, finding exponential inter-event time distributions with consistent rate parameters.