Amarylis Claudine Bonito Azeredo Wanschel

This study identifies the HIF-1 pathway as mediating the cardioprotective effects of GHRH-agonists in a murine model of cardiometabolic HFpEF.

This study shows estrogen and nitric oxide signaling reduce oxLDL uptake and oxidative stress in endothelial cells, modulate mitochondrial dynamics, and decrease inflammation, protecting against early atherosclerosis.

This paper identifies an O2-independent HIF-1 mechanism regulated by GH/IGF1/SST signaling that controls cardiomyocyte growth through metabolic shifts.

The paper investigates the postnatal fate of developmental gene regulatory networks in the heart, identifying persistent contributions from neural crest-derived cardiomyocytes.