Maya Jaffe

This study identifies how adipocyte secretome induces metabolic and epigenetic changes in TNBC cells, promoting stress-adaptive states through chromatin remodeling and metabolic reprogramming.

The paper shows that lipogenic metabolism in breast cancer cells disrupts Tet transgene activation by affecting chromatin remodeling substrates and cofactors.

This study shows that the adipocyte niche impairs T-cell function by modulating cytoskeletal dynamics and reducing TCR-antigen forces in both mice and human T-cells.

The paper develops a synthetic reader-actuator to activate silenced tumor suppressor genes in triple-negative breast cancer cells, reducing invasion and promoting apoptosis.