Alyssa L. Gagne

This study shows that deleting TUBB4A in human iPSCs reduces cell-autonomous deficits in oligodendrocytes and neurons associated with H-ABC, suggesting it could be a therapeutic strategy for TUBB4A-related leukodystrophy.

This study uses single-cell RNA-sequencing to analyze the individual and combined effects of Trisomy 21 and GATA1s on hematopoietic progenitor cells, revealing their impact on lineage skew and proliferation.

This paper creates an iPSC model of Multiple Sulfatase Deficiency, showing that neurons become more vulnerable to SUMF1 loss during differentiation.

The paper identifies CNVs in KOLF2.1J iPSCs linked to neurological disorders, showing they arose in vitro and affect gene expression in neural cells.

This study identifies TPM1 as a causal gene for hematopoietic traits using genome-wide association data and CRISPR/Cas9 knockout in iPSCs, showing enhanced in vitro hematopoiesis.