Author

Vi Pham

Children's Hospital of Philadelphia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Developmental Biology· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:protein structure prediction· 2 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Amaliris GuerraiD· 2 shared Arthur ChristopoulosiD· 2 shared Ben CapuanoiD· 2 shared Carlo Castruccio CastracaniiD· 2 shared Céline ValantiD· 2 shared David M. ThaliD· 2 shared Jesse I. MobbsiD· 2 shared Lars SchlotawaiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersMolecular Biology

Amaliris GuerraORCID

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Author profile →

5 papers

Recent·Most cited

Structure-guided allosteric modulation of the delta opioid receptor

Jesse I. Mobbs, M. Deborah Nguyen, Owindeep Deo, Damian Bartuzi, Hariprasad Venugopal, Sadia Alvi, Vi Pham, Nicholas Barnes, Arthur Christopoulos, Daniel P. Poole, Simona Carbone, Manuela Jörg, Ben Capuano, Jens Carlsson, Arisbel B. Gondin, , David M. Thal

The paper presents cryo-EM structures of the delta opioid receptor with PAMs, identifies a novel allosteric site, and describes a mechanism for enhanced binding and activation.

Nature Communications · Aug 22, 2026Peer-reviewedPharmacology & Toxicology

Structural basis of MK-97 positive allosteric modulation at the M4 mAChR

Michaela G. Kaoullas, Jesse I. Mobbs, Ziva Vuckovic, Matthew J. Belousoff, Fu Xiao, Keya Joshi, Jinan Wang, Nicholas W. Barnes, Vi Pham, Mahmuda Yeasmin, Geoff V. Thompson, Emma T. van der Westhuizen, Manuela Jörg, Ben Capuano, Andrew B. Tobin, , David M. Thal

This paper reports the cryo-EM structure of the M4 mAChR bound to MK-97 and acetylcholine, revealing how MK-97's binding mode improves PAM activity through distributed interactions.

bioRxiv · May 11, 2026 · PreprintPharmacology & Toxicology

TWIST1 Modulates Cilia Length, Endocytic Vesicle Dynamics, and Cell-Cell Junctions during Neural Tube Morphogenesis

Derrick Thomas, Bustamante Martínez, Zarna Lalwani, Vi Pham, Mary N Elmeniawi, An J. Tran, Jianming Xu, Irfan Saadi, Walid D. Fakhouri

The paper investigates TWIST1's role in neural tube morphogenesis by examining its effects on cilia length, endocytic vesicle dynamics, and cell-cell junctions in mutant embryos.

bioRxiv · Oct 3, 2025 · PreprintDevelopmental Biology

Effective Gene Therapy for Metachromatic Leukodystrophy Achieved with Minimal Lentiviral Genomic Integrations

Lucas Tricoli, Sunetra Sase, Julia Liao Hacker, Vi Pham, Maxwell Chappell, Laura Breda, Stephanie N. Hurwitz, Naoto Tanaka, Carlo Castruccio Castracani, Amaliris Guerra, Zhongqi Hou, Lars Schlotawa, Karthikeyan Radhakrishnan, Matthew Hogenauer, Aoife M. Roche, , Stefano Rivella

This paper develops a novel lentiviral vector for gene therapy of MLD that achieves high ARSA activity with minimal genomic integrations, improving safety and efficacy in preclinical models.

Molecular Therapy — Nucleic Acids · Jan 25, 2025Peer-reviewedMolecular Biology

Hematopoietic stem cell gene therapy improves outcomes in a clinically relevant mousemodel of Multiple Sulfatase Deficiency

Vi Pham, Lucas Tricoli, Xinying Hong, Parith Wongkittichote, Carlo Castruccio Castracani, Amaliris Guerra, Lars Schlotawa, Laura Ann Adang, Amanda Kuhs, Margaret M. Cassidy, Owen Kane, Emily Tsai, Maximiliano F Presa, Cathleen M. Lutz, Stefano Rivella, Rebecca C. Ahrens‐Nicklas

This study shows that SUMF1 gene therapy via hematopoietic stem cell transplant improves biochemical and functional outcomes in a mouse model of Multiple Sulfatase Deficiency.

Molecular Therapy · Aug 22, 2024Peer-reviewedNeuroscience