Margaret M. Cassidy

The paper investigates how transient prenatal hypoxia affects chromatin accessibility and transcriptional responses in mouse cortical neurons, linking these changes to long-term circuit dysfunction.

This study shows that SUMF1 gene therapy via hematopoietic stem cell transplant improves biochemical and functional outcomes in a mouse model of Multiple Sulfatase Deficiency.

This paper creates an iPSC model of Multiple Sulfatase Deficiency, showing that neurons become more vulnerable to SUMF1 loss during differentiation.

The paper integrates metabolomic, proteomic, and phospho-proteomic analyses of dorsal root ganglia from DPN donors and controls to identify molecular changes associated with diabetic neuropathic pain.

The paper identifies 844 differentially expressed genes in DRGs from DPN patients, showing increased inflammation and decreased neuronal genes, suggesting intraganglionic pathology in diabetic neuropathy.