Manu Ben Johny

This study investigates how calmodulin mutations affect voltage-gated calcium channel regulation in neurons, linking these effects to neurological symptoms in calmodulinopathies.

This study designs a de novo peptide modulator, ELIXIR, that inhibits pathogenic late sodium current in NaV channels, reversing dysfunction in cardiac arrhythmias and epilepsy models.

This paper develops GeeC, a genetically encoded actuator that boosts L-type CaV1.2/1.3 channel function in cardiomyocytes and neurons, enhancing calcium influx and excitation-transcription coupling.

The paper investigates how asymmetric conformational changes in CaV1.3 channels mediate voltage- and calcium-dependent inactivation through distinct molecular mechanisms.

The paper investigates tactile-auditory integration in mouse somatosensory cortices using two-photon imaging, finding robust inhibition in S2 and suggesting a local inhibitory circuit for spectral selection of inputs.