Younghoon Jang

This study shows that MLL3/MLL4 methyltransferase activities are essential for early embryonic development and stem cell differentiation, but their role is lineage-selective and not dependent on enhancer activation.

This study shows MED1 is essential for postnatal adipose expansion and de novo lipogenesis gene induction in mice, but not for adipose development or early adipogenesis.

This study shows that H3.3K4M destabilizes MLL3/4 proteins, preventing enhancer activation and impairing adipose tissue development.