Jürgen Weitz

This study develops an ex vivo drug sensitivity testing platform for rare solid tumors and finds that high in vitro sensitivity correlates with clinical benefit and progression-free survival.

This study reveals the structural and spatial organization of beta cell primary cilia in mouse and human islets, showing their interactions with neighboring cells and nerves, and their role in islet connectivity.

The paper shows that G3BP1/2 form condensates with insulin mRNA in beta cells, which dissolve upon glucose stimulation, regulating insulin mRNA storage and translation.

This study identifies transcriptomic changes in islet amyloidosis using RNA sequencing and finds a gene co-expression module linked to the condition.

This study uses multi-omics analysis of pancreatic islet donors to show heterogeneous beta cell changes associated with type 2 diabetes progression.

This study identifies miR-132 as critical for promoting mouse pancreatic beta cell regeneration through the Pten/Akt/Foxo3 signaling pathway.