Michele Solimena

The paper identifies a temperature- and lipid saturation-dependent transformation of ER membranes into rigid tubes under stress, driven by lipid demixing and protein segregation.

This study shows that cationic amphiphilic drugs (CADs) accumulate in insulin secretory granules via pH-dependent trapping, affecting monoamine storage and pH regulation.

This study shows that the Villin-SNAP25 interaction regulates insulin secretion by controlling secretory granule docking sites in response to glucose levels.

This study shows GLP-1R agonists improve mitochondrial health in beta-cells by forming a complex with VAPB and SPHKAP at ER-mitochondria MCSs, leading to mitochondrial remodelling and improved function.

This study shows that EVs deplete GGA2 in beta cells, causing Golgi acidification and altering the MHC class I immunopeptidome through premature cathepsin activation.

This study shows that somatostatin acting on primary cilia of pancreatic β-cells modulates cAMP and Ca2+ signaling, affecting β-cell function and linking cilia length to type-2 diabetes.

This study reveals the structural and spatial organization of beta cell primary cilia in mouse and human islets, showing their interactions with neighboring cells and nerves, and their role in islet connectivity.

The paper shows that G3BP1/2 form condensates with insulin mRNA in beta cells, which dissolve upon glucose stimulation, regulating insulin mRNA storage and translation.

This study identifies transcriptomic changes in islet amyloidosis using RNA sequencing and finds a gene co-expression module linked to the condition.

The paper introduces Islet Gene View (IGW), a platform that integrates gene expression and phenotypic data from pancreatic islets to explore T2D-related gene expression changes and their functional implications.

This study uses multi-omics analysis of pancreatic islet donors to show heterogeneous beta cell changes associated with type 2 diabetes progression.

This paper demonstrates how deep learning-based image restoration extends fluorescence microscopy's capabilities by improving resolution, reducing photon exposure, and increasing frame rates.

This study identifies miR-132 as critical for promoting mouse pancreatic beta cell regeneration through the Pten/Akt/Foxo3 signaling pathway.

This study uses FLIM to measure pH changes in aged insulin secretory granules and shows that Exendin-4 re-acidifies old granules, suggesting a mechanism for their rejuvenation.