Cancer BiologyeLifePeer-reviewed
SOD1 is a synthetic lethal target in PPM1D-mutant leukemia cells
Linda Zhang, Joanne I. Hsu, Etienne D. Braekeleer…·Margaret A. Goodell
This study identifies SOD1 as a synthetic lethal target in PPM1D-mutant leukemia cells through CRISPR/Cas9 screening, revealing a dysregulated redox landscape and potential therapeutic strategy.