Author

Clément Chapat

Centre National de la Recherche ScientifiqueORCID 0000-0002-5806-7959Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Developmental Biology· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Clara MochiD· 2 shared Alexis‐Pierre BemelmansiD· 1 shared Alice DavyiD· 1 shared Anaïs AstieriD· 1 shared Anne-Cécile BoulayiD· 1 shared Bérangère LombardiD· 1 shared Carine FromentiD· 1 shared Célia Plisson‐ChastangiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersCell Biology

Clara MochORCID

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4 papers

Recent·Most cited

Molecular BiologyHemaSpherePeer-reviewedJun 1, 2026

Translatome and translation dynamics analysis of a RiboCancer cell line panel reveals that leukemia-associated Rps15 mutations rewire translation through codon-specific tRNA accommodation defects.

Anaïs Astier, Marino Caruso, Stijn Vereecke…·Kim De Keersmaecker

The paper analyzes translatome and translation dynamics in RiboCancer cell lines to show that Rps15 mutations disrupt tRNA accommodation, affecting translation efficiency and transcriptional regulation in CLL.

2 citations

humanRibo-seq

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Developmental BiologybioRxivPreprintSep 10, 2024

Acute dietary methionine restriction highlights sensitivity of neocortex development to metabolic variations

Sulov Saha, Clémence Debacq, Christophe Audouard…·Alice Davy

This study shows that acute methionine restriction during mouse neocortex development severely reduces growth and neuronal production, but this effect is reversible with dietary recovery.

2 citations

mouseexperimental assay

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Cell BiologybioRxivPreprintNov 20, 2023

The YTHDF1-3 proteins are bidirectionally influenced by the codon content of their mRNA targets

Clara Moch, Limei Zou, Nicolas Pythoud…·Clément Chapat

This study identifies that YTHDF1-3 proteins modulate mRNA translation and stability based on codon content, revealing bidirectional regulation of mRNA fate.

6 citations

humanproteomics

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NeurosciencebioRxivPreprintJul 16, 2022

Translational regulation by RACK1 in astrocytes represses KIR4.1 expression and regulates neuronal activity

Marc Oudart, Katia Avila‐Gutierrez, Clara Moch…·Martine Cohen‐Salmon

This study identifies RACK1 as a repressor of KIR4.1 translation in astrocytes, showing its role in regulating neuronal activity through modulation of KIR4.1 expression.

DOI 10.1101/2022.07.16.500292

mouseproteomics

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