Chrysothemis C. Brown

This study identifies PD-L2's role on dendritic cells in restraining CD8+ T cell immunity in tumors, showing distinct functions from PD-L1 and suggesting therapeutic implications for PD-L2 blockade.

This study identifies Runx/Cbfβ transcriptional factor complexes as regulators of Thetis cell subset development and Rorγt+ pTreg cell induction.

This paper benchmarks cell type deconvolution methods in spatial transcriptomics, finding that a simple marker gene scoring approach performs well, especially for rare cell types, and applies it to study anti-PD1 immunotherapy in a mouse model.

The paper shows that TCRs from Tregs are more effective than Tconv TCRs in driving pTreg differentiation, with distinct phenotypes based on antigen type.

This study identifies Thetis cells IV as essential for food-specific Treg cell differentiation and oral tolerance, highlighting their distinct role from dendritic cells in immune regulation.

The paper reanalyzes single-cell RNA-seq data from three studies to reconcile discrepancies in identifying RORγt+ antigen-presenting cells and their role in pTreg induction.

SEACells identifies metacells from single-cell data, improving gene-peak associations and revealing chromatin dynamics in hematopoiesis and COVID-19.