Author

Frédéric Paquin-Lefebvre

École Normale Supérieure - PSLORCID 0000-0002-5840-5049Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Assay:imaging· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Assay:electrophysiology· 1 Approach:experimental assay· 1 Research Focus:spatial domain detection· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

David HolcmaniD· 2 shared Eduard KorkotianiD· 1 shared Jürgen ReingruberiD· 1 shared Liliia KushnirevaiD· 1 shared Matteo DoraiD· 1 shared Nathalie RouachiD· 1 shared Samuel Kubler· 1 shared Simon B. LaughliniD· 1 shared

Activity by Year

2013-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersNeuroscience

David HolcmanORCID

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3 papers

Recent·Most cited

BiophysicsbioRxivPreprintMay 15, 2026

Electrodiffusion analysis of concentration and voltage changes in thin cylindrical domains using cross-diffusion modelling

Frédéric Paquin-Lefebvre, Jürgen Reingruber

This paper derives analytic current-voltage-concentration relations for narrow cylindrical domains using cross-diffusion equations, showing how ion influx affects voltage and other ions' concentrations.

DOI 10.64898/2026.05.13.724841

electrophysiologydeep learning

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NeurosciencebioRxivPreprintMar 11, 2026

Synaptic Input Triggers On-Demand Spine-Specific Mitochondrial ATP Production and Delivery

Frédéric Paquin-Lefebvre, Liliia Kushnireva, Zelai Xu…·David Holcman

The paper shows synaptic input triggers on-demand mitochondrial ATP production and delivery in spines with a spine apparatus, optimized by geometry and calcium signaling.

DOI 10.64898/2026.03.09.708229

imagingexperimental assay

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Cell BiologyMethods in molecular biologyPeer-reviewedFeb 24, 2012

Analyzing photoactivation with diffusion models to study transport in the Endoplasmic Reticulum network

Matteo Dora, Frédéric Paquin-Lefebvre, David Holcman

The paper uses diffusion models to analyze photoactivation data and infer biophysical properties of molecular transport in the Endoplasmic Reticulum network.

1 citation

imagingdeep learning

𝕏 PostBluesky