Charles Edward Chalfant

This study identifies a novel lipid signaling pathway involving iPLA2β that links ER stress to β-cell apoptosis in T1D, revealing transcriptional regulation by iDLs and potential therapeutic targets.

This study identifies CyKILRb as an oncogenic long non-coding RNA that promotes tumorigenesis by upregulating PIK3R2 and activating the PI3K/AKT pathway.

This study shows that inhibiting acid ceramidase (AC) enhances venetoclax's effectiveness in venetoclax-resistant AML by inducing a cytotoxic integrated stress response.

This study identifies a bioenergetic mechanism in AML cells where mitochondria consume ATP to resist chemotherapy, offering a target for improving treatment.

The paper identifies a long non-coding RNA, CyKILR, with two splice variants that have opposing effects on tumor growth and cell survival in NSCLC.

This study evaluates the anti-leukemic effects of LCL-805, an acid ceramidase inhibitor, in AML cell lines and patient samples, showing it promotes iron-dependent cell death by antagonizing Akt signaling.