Lukas Stefan Tombor

This study identifies vascular niches as key hotspots for age-related inflammation and fibrosis in cardiac tissue using single-nucleus RNA sequencing and spatial transcriptomics.

This study identifies adventitial leptin receptor-expressing fibroblasts as key contributors to cardiac fibrosis after myocardial infarction in mice and humans.

This study identifies ZBTB16 as a critical regulator of endothelial function in aging, showing its protective role against cardiac dysfunction through suppression of pro-fibrotic signaling.

This study shows that loss of RGS5 in pericytes with age leads to cardiac dysfunction and fibrosis by altering pericyte function and activating fibroblasts.

The paper introduces a cross-species integration pipeline for scRNA-seq data, validated on heart failure datasets from mice and humans, improving ortholog assignment and enabling pathway comparison.

This study compares common scRNA-seq alignment tools, finding differences in runtime, cell and gene detection, and potential artifacts, highlighting the impact of mapping strategies on analysis outcomes.