NeurosciencebioRxivPreprint
Brain cholesterol metabolites cause significant neurodegeneration in human iPSC-derived neurons
Yuqing Feng, Bismoy Mazumder, Tasuku Konno…·Gabriele S. Kaminski Schierle
This study shows that 24S-HC and 27-HC, brain cholesterol metabolites, cause neuronal dysfunction in human iPSC-derived neurons by disrupting calcium signaling, organelle function, and alpha-synuclein accumulation.
DOI 10.1101/2025.06.10.656594