Stefan Schulz

The paper investigates how GPCR domains influence β-arrestin functions and conformational changes, revealing domain-specific effects on signaling outcomes.

The paper investigates the role of GRK subfamilies in phosphorylation of the MOR C-tail and their impact on β-arrestin2 recruitment, showing GRK2/3 and GRK5/6 have distinct contributions.

This study examines opioid-induced changes in brain activation and functional connectivity in awake mice, finding that dysconnectivity correlates with analgesia.

This study shows chronic morphine induces sex-specific, projection-dependent adaptations in MOR signaling in thalamo-cortico-striatal circuits, mediated by MOR phosphorylation.

This study identifies SST1 and SST4 as redundant regulators of neprilysin, a key amyloid beta-degrading enzyme, and shows that targeting these receptors reduces Aβ pathology and improves cognition in an AD mouse model.

This study investigates mu-delta opioid receptor heteromerization in neurons, showing co-internalization and altered trafficking, with implications for nociceptive transmission.