Thaddeus S. Stappenbeck

This study shows that gut microbe-derived short-chain fatty acids reduce joint inflammation after alphavirus infection by modulating immune cell activity.

This study shows that intestinal stem cells (ISCs) enhance local mucosal immunity by engulfing apoptotic bodies, which leads to increased T cell activity through TNF signaling.

This study develops a PSC-IBD mouse model and shows that dysbiotic microbiota and bile acid metabolism drive colitis and carcinogenesis.

This study compares droplet-based and picowell-based single-cell RNA sequencing platforms for human colon biopsies, finding differences in cell recovery, typeability, and gene expression consistency.

This paper develops an in vitro model of the human intestinal epithelium that closely mimics in vivo cell types using single-cell transcriptomics and a biomedical foundation model.

This paper develops a deep learning model to classify glomeruli as normal or sclerotic in frozen kidney biopsy slides, achieving performance comparable to expert pathologists with limited training data.