Yorgo Modis

This study identifies ZNFX1 as a multifunctional enzyme in innate immunity that couples RNA sensing to ubiquitin signaling and assembles into higher-order structures for signal amplification.

The paper characterizes Atlas virus capsid structures and demonstrates their potential as engineerable nanoparticle scaffolds for targeted nucleic acid delivery.

This paper reports the crystal structure of the HERV-K HML-2 envelope glycoprotein surface subunit, revealing structural features relevant to autoimmunity and drug targeting.

This study shows MORC2 regulates CpG methylation of active LINE-1 retrotransposons during human neurodevelopment, similar to the piRNA pathway in the germline.

The paper identifies MDA5 variants that protect against autoimmune diseases but increase IBD risk, showing a trade-off between antiviral activity and autoimmunity.

This study investigates how autoimmune-protective MDA5 variants affect RNA sensing and signaling, finding they reduce interferon response and alter filament formation and ATP hydrolysis.

This study reports the crystal structure of MPP8's C-terminal domain and its interaction with HUSH complex components, revealing its role in recruiting H3K9 methyltransferases to promote heterochromatinization.

This study shows MDA5 compacts dsRNA via ATP-dependent loop extrusion, stabilizing the structure through CARD domain oligomerization.

The paper identifies a novel endogenous retrovirus in hookworms with an envelope protein structurally similar to phlebovirus glycoproteins and functional fusogenic activity.

The paper identifies TASOR as a pseudo-PARP essential for HUSH complex assembly and epigenetic repression of transposons.

The paper shows MAVS polymers induced by dsRNA are smaller than 80 nm and require the transmembrane domain for mitochondrial remodeling and interferon signaling.