Marianna Kruithof‐de Julio

The paper uses spatial single-cell proteomics to map multicellular niches in primary prostate cancer, identifying prognostic cell types and niches beyond Gleason grading.

This study identifies iron metabolism as a therapeutic target in stem cell-like castration-resistant prostate cancer by showing that inhibiting NRF2 induces ferroptosis in CD44hi cells.

The paper optimizes dissociation protocols and uses multimodal profiling to characterize fibromuscular stromal heterogeneity in prostate cancer with clinical relevance.

This paper develops a Lung-on-Chip model to study SARS-CoV-2 infection in the alveolar barrier and demonstrates its utility for drug testing.

The paper introduces TransCistor, a framework to identify cis-regulatory lncRNAs with controlled false discovery rates, finding that only a minority of lncRNAs are cis-acting, primarily as activators.

This paper introduces VirtualMultiplexer, a generative AI tool that translates H&E images to IHC images, improving clinical predictions and accelerating histopathology workflows.

The paper identifies mutated long noncoding RNAs (lncRNAs) as contributors to tumour cell fitness through experimental validation of their oncogenic effects.

This study uses patient-derived organoids to investigate drug sensitivity in multifocal prostate cancer and develops a transcriptomics-based model to predict drug responses.