Patrick Chames

This paper designs modular DNA-Nanobody engagers to tune T-cell immunological synapses for precision immunotherapy, showing linker-length effects on cytotoxicity and cytokine release.

Celldetective is an AI-enhanced image analysis tool for analyzing dynamic cell interactions in immunology and immunotherapy assays.

This paper introduces a genetic method to modify sEV surfaces with nanobodies, showing enhanced uptake by target cells.

This study shows that chronic activation of mGlu2 receptors with a nanobody accelerates amyloid formation and worsens memory deficits in Alzheimer's disease models.

This study demonstrates that non-targeted immunization and panning can isolate PSMA-targeting nanobodies from phage display libraries.

This study shows that bivalent natalizumab inhibits VLA-4 adhesion more effectively than monovalent Fab fragments under shear stress, suggesting kinetic and geometric factors are critical for therapeutic efficacy.

This paper identifies and characterizes nanobodies targeting human Glypican-4, showing they bind with high affinity and functionally inhibit hGPC4 activity in human pluripotent stem cells.

This study identifies cross-species reactive VHHs targeting a novel TfR1 epitope, enabling efficient BBB crossing for CNS drug delivery.

The paper measures cytotoxicity of bispecific antibodies using NK cells and introduces a model to decouple host response from engager characteristics.

This paper develops a microfluidic assay to select yeast-displayed nanobodies based on antigen density and applied force, enabling enrichment of binders with both high affinity and force resistance.

This study measures antigen-antibody bond behavior under force using nanobodies and flow chamber assays, revealing catch bond properties and NK cell mechanosensitivity.