Thomas F. Meyer

This study investigates how infection and pesticide exposure lead to α-Synuclein Ser129 phosphorylation through c-Abl kinase activation and identifies potential therapeutic targets.

This study shows that inhibiting ADAM17 enhances cisplatin's cytotoxic effect in cervical cancer spheroids and organoids, suggesting ADAM17 as a potential target for overcoming chemoresistance.

This study shows that Helicobacter pylori's CagA protein induces intestinal metaplasia in human gastric organoids by activating STAT3 and increasing intestinal markers.

The paper maps DNA methylation and transcriptomes across human stomach regions, showing limited transcriptomic regulation by methylation and identifying region-specific transcription factors.

SOPRA is a method for analyzing high-content screens by regressing non-averaged cell feature data to identify significant changes in cell populations.

The paper identifies the spatial organisation and regulatory mechanisms of epithelial lineages at the gastroesophageal junction using multi-omics approaches and shows that Wnt microenvironments maintain homeostasis without lineage plasticity.

The paper uses bulk and single-cell transcriptomics to analyze SARS-CoV-2 infection in human cell lines, identifying HSP90 as a potential therapeutic target.

The paper identifies ALPK1 and TIFA as key components of an innate immune response triggered by H. pylori's T4SS, independent of CagA translocation.