Markus Landthaler

The paper quantifies gene expression noise in mammalian cells using single-cell proteomics and finds that noise is largely extrinsic and structured across cellular states.

This study shows that MNK1 and MNK2 have distinct roles in social and cognitive behaviors by regulating different aspects of the synaptic proteome and phosphoproteome in knockout mice.

The paper identifies CRISPRa-responsive enhancers and their target genes in a 2 Mb region around PHOX2B using TESLA-seq, revealing both known and novel regulatory relationships.

This study rapidly depletes UPF1 in human cells to investigate NMD-regulated transcriptome dynamics, identifying core transcripts and biological processes affected.

This study creates a single-cell atlas of gene expression, transcription, and chromatin accessibility in sea urchin embryos, revealing dynamic regulatory elements and lineage-specific gene activation patterns.

This paper demonstrates that iPSC-derived skin organoids support MCPyV infection, persistence, and tumor development, providing a model to study viral interactions with the immune system and treatment strategies.

This study uses human hair-bearing skin organoids to investigate HSV-1 infection and host responses, revealing cell-type-specific susceptibility and spatially organized immune reactions.

The paper investigates the role of five RNA-binding proteins in HSV-1 transcription and their impact on viral replication, finding that SPT5 is essential for immediate-early gene expression while SFPQ has a different regulatory role.

The paper measures mRNA flow rates between subcellular compartments in mouse embryonic stem cells and identifies nuclear retention as the rate-limiting step for many mature mRNAs.

This paper uses neural networks to match disease states between human and hamster COVID-19 scRNAseq data, finding similar cellular responses in specific cell types across species.

The paper longitudinally analyzes wastewater viromes to track viral diversity and detect pathogens, identifying thousands of novel viral transcripts.

This study shows DNA virus infections activate transposable elements (TEs) through KAP1/TRIM28 inhibition and DUX4 expression, with in vivo correlations in cancer patients.

The paper presents an AI-guided pipeline for PPI drug discovery, identifying a SARS-CoV-2 inhibitor by combining experimental assays, machine learning, and virtual screening.

VoltRon is an R package for spatial omics analysis that integrates multi-resolution and multi-omics data through image registration and spatial alignment.

This paper identifies M35 as a viral protein that binds DNA and inhibits IRF3-mediated gene expression, including Ifnb1, thereby suppressing the antiviral type I IFN response.

This study links gut microbiota dysbiosis and altered tryptophan metabolism to increased inflammation in severe COVID-19 patients.

The paper measures translation dynamics in mouse neocortex neurogenesis, revealing a critical period of translational control that regulates protein expression and neuronal differentiation.

The paper introduces iKiP-DB, a database that predicts kinase activity from phosphoproteomic data, showing its effectiveness in analyzing both well-known and understudied kinases.

The paper evaluates dexamethasone and anti-SARS-CoV-2 antibodies in hamster models, showing reduced viral burden with antibodies and anti-inflammatory effects with dexamethasone, with synergistic benefits when combined.

This study uses single-nuclei transcriptomics to analyze human kidney injury responses, identifying four injury-associated cell states and showing similar gene expression changes between AKI patients with and without COVID-19.

The paper uses spatial transcriptomics and single-cell RNA labeling to study mRNA localization and dynamics in early zebrafish embryos, revealing transport to primordial germ cells and evolutionary conservation.

This study shows that ZAP restricts HCMV infection by destabilizing viral transcripts with low CG content, revealing its role in antiviral defense against DNA viruses.

This study identifies mRNAs regulated by DDX3 depletion using ribosome profiling and RNA-seq, showing DDX3 preferentially affects a subset of transcripts with complex 5' UTRs.

This study infects human brain organoids with HSV-1 and identifies molecular and cellular changes associated with neurodegeneration.

The paper uses bulk and single-cell transcriptomics to analyze SARS-CoV-2 infection in human cell lines, identifying HSP90 as a potential therapeutic target.

The paper identifies CRNKL1 as a regulator that enhances nuclear retention of intron-retaining HIV-1 and cellular mRNAs, affecting their cytoplasmic levels.

The paper reveals Ebp1's role in neuronal proteostasis by analyzing ribosomal architecture and proteomic changes in the developing mouse neocortex.

The paper uses single-cell RNA-sequencing to study HSV-1 infection in human fibroblasts, identifying NRF2 activation as an antiviral response that reduces virus production.

The paper shows that codon bias affects mRNA stability in humans through ILF2, with GC3 codons stabilizing and AT3 codons destabilizing mRNA.