Keene L. Abbott

This study shows that physiological folate levels limit nucleotide synthesis in leukemia cells, making them reliant on salvage pathways for proliferation.

This study shows pancreatic cancer disrupts normal pancreatic function, leading to systemic nutrient depletion and muscle wasting, with autophagy in muscle playing a key role in nutrient redistribution to support tumor growth.

This study uses intraoperative arteriovenous sampling to measure tumor metabolism in NSCLC patients, revealing distinct metabolic profiles between tumor and normal lung tissue.

The paper investigates how amino acid limitation affects translation by analyzing ribosome stalling and the role of RQC pathways and RNF14 in response to arginine depletion.

This study shows that single nutrients do not determine breast cancer metastasis sites, and identifies purine synthesis as a key factor across multiple tissues.

This study compares nutrient levels in plasma and bone marrow of pediatric B-ALL patients, identifying metabolic differences between subtypes and highlighting unique metabolic features in B-ALL circulation.

The paper identifies sideroflexins as mitochondrial transporters for neutral amino acids and shows functional overlap among paralogues.

The paper shows cancer cells adjust mitochondrial respiration to alter NAD+/NADH ratios, enhancing biomass synthesis and proliferation under nutrient limitation.

This study profiles metabolites in renal cell carcinoma tissue and fluid to show that nutrient availability is more influenced by tissue-specific factors than tumor-driven changes.